Continue reading → Posted by Marko in Publications, 0 commentsĮmma-Ruoqi Xu, Aleix Lafita, Alex Bateman, Marko HyvönenĪcta Crystallographica Section D Structural Biology D76:124-134 (2020)
vesca, and then compares findings with orthologs in Arabidopsis thaliana. This work describes the genomic organization of the RALF gene families in commercial octoploid strawberry (Fragaria × ananassa) and the re-annotated genome of F. Previous studies have identified nine RALF genes in the diploid strawberry (Fragaria vesca) genome.
In addition, peptides homologous to RALF are secreted by different fungal pathogens as effectors during early stages of infection. Their involvement in host-pathogen crosstalk as negative regulators of immunity in Arabidopsis has also been recognized. They play multiple roles as hormonal signals in diverse processes, including root elongation, cell growth, pollen tube development, and fertilization. Rapid Alkalinization Factors (RALFs) are cysteine-rich peptides ubiquitous within plant kingdom. Continue reading → Posted by Marko in Publications, 0 commentsįrancesca Negrini, Kevin O’Grady, Marko Hyvönen, Kevin M Folta, Elena Baraldi Spectroscopic, structural, and computational studies showed that the stapling linkers of the peptides contribute to their binding. Apparent dissociation constants are in the picomolar-to-low nanomolar range for those isomers with diarylethene in the “open” configuration, but up to eight times larger for the corresponding “closed” isomers.
The corresponding photoisomers possess significantly different affinities to the p53-interacting domain of the human MDM2. Organic and Biomolecular Chemistry, 2020 May 11, Advance article in pressĪnalogs of the known inhibitor (peptide pDI) of the p53/MDM2 protein-protein interaction are reported, which are stapled by linkers bearing a photoisomerizable diarylethene moiety. Alexander V Strizhak, Oleg Babii, Sergii Afonin, Iuliia Bakanovic, Teodors Pantelejevs, Wenshu Xu, Elaine Fowler, Rohan Eapen, Krishna Sharma, Maxim O Platonov, Vasyl V Hurmach, Laura Itzhaki, Marko Hyvönen, Anne S Ulrich, David R Spring, Igor V Komarov
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